Additional Publications: Image
2015
Riera, C.E., and Dillin, A. (2015).
Can aging be "drugged"?
Nat. Med, 2015 Dec 8;21(12):1400-5. PMID: 26646496
Additional Publications: About
Heimbucher T, Liu Z, Bossard C, McCloskey R, Carrano A, Riedel C. Tanasa B, Klammt C, Fonslow B, Riera C, Lillemeier B, Kemphues K, Yates J, O'Shea C. Hunter T, Dillin A.
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function In Metabolism and Longevity.
Cell Metabolism 22, 151-163, July 7, 2015. PMID: 26154057
Additional Publications: About
Riera CE, Dillin A.
Tipping the metabolic scales towards increased longevity in mammals.
Nat Cell Biolo. 2015 Feb 27;17(3):196-203. PMID: 25720959
Additional Publications: About
Schinzel R, Dillin A.
Endocrine aspects of organelle stress - cell non-autonomous signaling of mitochondria and the ER.
Curr Opin Cell Biol. 2015 Feb 9;33C:102-110. PMID: 25677685.
Additional Publications: About
Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M.
Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy.
Mol Cell. 2015 Jan 8;57(1):55-68. PMID: 25544559
Additional Publications: About
2014
Vilchez D, Seaz I, Dillin A.
The role of protein clearance mechanisms in organismal ageing and age-related diseases.
Nat Commun. 2014 Dec 8;5:5659. PMID: 25482515
Additional Publications: About
Dillin A.
Profile of Kazutoshi Mori and Peter Walter, 2014 Lasker Basic Medical Research awardees: The unfolded protein response.
Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17696-7. PMID: 25480547
Additional Publications: About
Mardones P, Dillin A, Hetz C.
Cell-nonautonomous control of the UPR: mastering energy homeostasis.
Cell Metab. 2014 Sep 2;20(3):385-7. PMID: 25185942
Additional Publications: About
Patti GJ, Tautenhahn R, Johannsen D, Kalisiak E, Ravussin E, Brüning JC, Dillin A, Siuzdak G.
Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension.
Metabolomics. 2014 Aug 1;10(4):737-743. PMID: 25530742
Additional Publications: About
Fonslow BR, Moresco JJ, Tu PG, Aalto AP, Pasquinelli AE, Dillin AG, Yates III, JR.
Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes.
Additional Publications: About
Carrano AC, Dillin A, Hunter T.
A Kruppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.
Additional Publications: About
Douglas PM, Dillin A.
The disposable soma theory of aging in reverse.
Additional Publications: About
Taylor RC, Berendzen KM, Dillin A.
Systemic stress signalling: understanding the cell non-autonomous control of proteostasis.
Nat Rev Mol Cell Biol. 2014;15(3):211-7. PMID: 24556842
Additional Publications: About
Dillin A, Gottschling DE, Nystrom T.
The good and the bad of being connected: the integrons of aging.
Curr Opin Cell Biol.;26:107-12. PMID: 24529252
Additional Publications: About
2013
Le Coutre J, Mattson MP, Dillin A, Friedman J, Bistrian B.
Nutrition and the biology of human ageing: cognitive decline/food intake and caloric restriction.
J Nutr Health Aging. 2013;17(8):717-20. PMID: 24097030
Additional Publications: About
Vilchez D, Simic MS, Dillin A.
Proteostasis and aging of stem cells.
Trends in cell biology. 2013. PMID: 24094931
Additional Publications: About
Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A.
FOXO4 is necessary for neural differentiation of human embryonic stem cells.
Aging Cell. 2013;12(3):518-22. PMID: 23551888
Additional Publications: About
Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M.
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
Additional Publications: About
Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL.
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.
Nat Cell Biol. 2013 Jul;15(7):741-50. PMID: 23685627
Additional Publications: About
Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G.
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.
Nat Cell Biol. 2013 May;15(5):491-501. PMID: 23604319
Additional Publications: About
Parrish AR, She X, Xiang Z, Coin I, Shen Z, Briggs SP, Dillin A, Wang L.
Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs.
ACS Chem Biol. 2012 Jul 20;7(7):1292-302. PMID: 22554080
Additional Publications: About
Wilkinson DS, Taylor RC, Dillin A.
Analysis of aging in Caenorhabditis elegans.
Methods Cell Biol. 2012;107:353-81. PMID: 22226530
Additional Publications: About
2011
Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A.
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Nature. 2011;470(7334):404-8. PMID: 21331044
Additional Publications: About
Dillin A, Cohen E.
Aging and protein aggregation-mediated disorders: from invertebrates to mammals.
Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):94-8. PMID: 21115535
Additional Publications: About
Taylor RC, Dillin A.
Aging as an event of proteostasis collapse.
Cold Spring Harb Perspect Biol. 2011;3(5). PMID: 21441594
Additional Publications: About
Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA.
Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia.
Mol Cell. 2011; 44(4):532-44. PMID: 22099302
Additional Publications: About
Mair W, Steffen KK, Dillin A.
SIP-ing the elixir of youth.
Cell. 2011;146(6):859-60. PMID: 21925309
Additional Publications: About
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ.
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Science. 2011;331(6016):456-61. PMID: 21205641
Additional Publications: About
2010
Volovik Y, Maman, M, Dubnikov, T, Bejerano-Sagie,M, Joyce D, Kapernick EA, Cohen E, Dillin A.
Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection.
Aging Cell.2010;9(2):126-34. PMID: 22360389
Additional Publications: About
Douglas PM, Dillin A.
Protein homeostasis and aging in neurodegeneration.
J Cell Biol. 2010;190(5):719-29. PMID: 20819932
Additional Publications: About
Dillin A.
Andy Dillin: Using aging research to probe biology. Interview by Caitlin Sedwick.
J Cell Biol. 2010;189(4):616-7. PMID: 20479463
Additional Publications: About
2009
Mair W, Panowski SH, Shaw RJ, Dillin A.
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
PLoS One. 2009;4(2):e4535. PMID: 19229346
Additional Publications: About
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A.
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.
Cell. 2009;139(6):1157-69. PMID: 20005808
Additional Publications: About
Carrano AC, Liu Z, Dillin A, Hunter T.
A conserved ubiquitination pathway determines longevity in response to diet restriction.
Nature. 2009;460(7253):396-9. PMID: 19553937
Additional Publications: About
Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE.
Biological and chemical approaches to diseases of proteostasis deficiency.
Annu Rev Biochem. 2009;78:959-91. PMID: 19298183
Additional Publications: About
Panowski SH, Dillin A.
Signals of youth: endocrine regulation of aging in Caenorhabditis elegans.
Trends Endocrinol Metab. 2009;20(6):259-64. PMID: 19646896
Additional Publications: About
Shaw R, Dillin A.
PPTR-1 counterAkts insulin signaling.
Additional Publications: About
2008
Mair W, Dillin A.
Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008;77:727-54. PMID: 18373439
Additional Publications: About
Cohen E, Dillin A.
The insulin paradox: aging, proteotoxicity and neurodegeneration.
Nature reviews Neuroscience. 2008;9(10):759-67. PMID: 18769445
Additional Publications: About
Balch WE, Morimoto RI, Dillin A, Kelly JW.
Adapting proteostasis for disease intervention.
Science. 2008;319(5865):916-9. PMID: 18276881
Additional Publications: About
Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J.
C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins.
Cell. 2008;132(5):745-57. PMID: 18329362
Additional Publications: About
2007
Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A.
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
Nature. 2007;447(7144):550-5. PMID: 17476212
Additional Publications: About
Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR.
Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.
Science. 2007;317(5838):660-3. PMID: 17673661
Additional Publications: About
Durieux J, Dillin A.
Mitochondria and aging: dilution is the solution.
Additional Publications: About
2006
Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A.
Opposing activities protect against age-onset proteotoxicity.
Science. 2006;313(5793):1604-10. PMID: 16902091
Additional Publications: About
Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A.
SMK-1, an essential regulator of DAF-16-mediated longevity.
Cell. 2006;124(5):1039-53. PMID: 16530049
Additional Publications: About
Wolff S, Dillin A.
The trifecta of aging in Caenorhabditis elegans.
Experimental gerontology. 2006;41(10):894-903. PMID: 16919905
Additional Publications: About
2005
Raices M, Maruyama H, Dillin A, Karlseder J.
Uncoupling of longevity and telomere length in C. elegans.
PLoS Genet. 2005;1(3):e30. PMID: 16151516
Additional Publications: About
Hansen M, Hsu AL, Dillin A, Kenyon C.
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.
PLoS Genet. 2005;1(1):119-28. PMID: 16103914
Additional Publications: About
Aguilaniu H, Durieux J, Dillin A.
Metabolism, ubiquinone synthesis, and longevity.
Genes & development. 2005;19(20):2399-406. PMID: 16230529
Additional Publications: About
Pre 2005
Venable JD, Dong MQ, Wohlschlegel J, Dillin A, Yates JR.
Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra.
Nature Methods. 2004;1(1):39-45. PMID: 15782151
Additional Publications: About
Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C.
Rates of behavior and aging specified by mitochondrial function during development.
Science. 2002;298(5602):2398-401. PMID: 12471266
Additional Publications: About
Dillin A, Crawford DK, Kenyon C.
Timing requirements for insulin/IGF-1 signaling in C. elegans.
Science. 2002;298(5594):830-4. PMID: 12399591
Additional Publications: About
Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C.
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
Science. 2002;295(5554):502-5. PMID: 11799246
Additional Publications: About
Dillin A, Rine J.
Roles for ORC in M phase and S phase.
Science. 1998;279(5357):1733-7. PMID: 9497294
Additional Publications: About
Dillin A, Rine J.
Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.
Genetics. 1997;147(3):1053-62. PMID: 9383052
Additional Publications: About
McCracken AA, Karpichev IV, Ernaga JE, Werner ED, Dillin AG, Courchesne WE.
Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor.
Genetics. 1996;144(4):1355-62. PMID: 8978025
Additional Publications: About
Loo S, Laurenson P, Foss M, Dillin A, Rine J.
Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae.
Genetics. 1995;141(3):889-902. PMID: 8582634
Additional Publications: About
Fox CA, Loo S, Dillin A, Rine J.
The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.
Genes & Development.1995;9(8):911-24. PMID: 7774809
Additional Publications: About
Dillin A, Rine J. On the origin of a silencer.
Trends Biochem Sci. 1995;20(6):231-5. PMID: 7631420
Additional Publications: About
