Publications

2020

Metcalf, MG, Higuchi-Sanabria, R, Garcia, G, Tsui, K, and Dillin, A

Beyond the cell factory: Homeostatic regulation of and by the UPRER

Sci Adv. 15 July 2020: 6(29):eabb9614. PMID: 32832649

Webster BM, Gildea HK, Dillin A.

Protein homeostasis from the outside in

Nat Cell Biol.  08 July 2020: Vol. 22, 911-912. PMID: 32641767  

Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, Monshietehadi S, Dallarda S, Pender C, Pon LA, Zoncu R, Dillin A.

Lysosomal recycling of amino acids affects ER quality control.

Sci Adv.  26 June 2020: 6(26):eaaz9805.  PMID: 32637599

Bar-Ziv R, Bolas T, Dillin A. 

Systemic effects of mitochondrial stress.

EMBO Reports.  24 May 2020: 21: e50094. PMID: 32449292  

Bar-Ziv, R, Frakes, AF, Higuchi-Sanabria, R, Bolas, T, Frankino, P, Gildea, H, Metcalf, M, and Dillin, A.

Measurements of physiological stress responses in C. elegans. 

JOVE.  In Press.  

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Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Higuchi-Sanabria R, Dillin A. 

Four glial cells regular ER stress resistance and longevity via neuropeptide signaling. 

Science.  24 Jan 2020: Vol. 367, Issue 6476, pp. 436-440. PMID:  31974253  

Daniele J, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes S, Kelet N,  Sanchez M, Metcalf M, Garcia G, Frankino P, Benitez C, Zeng M, Esping S, Joe L, & Dillin A. 

A non-canonical UPRER promotes lipophagy to extend lifespan.   

Science Advances.  2020 Jan 1; (6) 1:1-9.  PMID:  31911951   

2019

Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A. 

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. 

Cell. 2019 Nov 27;179(6):1306-1318.  PMID:  31761535

Anderson EC, Frankino PA, Higuchi-Sanabria R, Yang Q, Bian Q, Podshivalova K, Shin A, Kenyon C, Dillin A, Meyer BJ. 

X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.

Dev Cell. 2019 Oct 21;51(2):192-207.    PMID:  31495695   pdf

Simic M, Moehle E, Schinzel, R, Lorbeer F, Halloran J, Heydari, K , Sanchez M, Jullié D , Hockemeyer D , Dillin A. 

Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming.   

Science Advances.  2019 April 20.  PMID:  30989118   pdf

2018

Higuchi-Sanabria R, Paul JW, Durieux J, Benitez C, Frankino PA, Tronnes SU, Garcia G, Daniele JR, Monshietehadi S, Dillin A. 

Spatial regulation of the actin cytoskeleton by HSF-1 dring aging. 

Mol Biol Cell.  2018 Aug 22.  PMID:  30133343   pdf  

Zhang, Q, Wu, X, Chen P, Liu, L, Xin, N, Tian Y, Dillin, A. 

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.   

Cell.  2018 Aug 9.  PMID:  30057120

Daniele JR, Heydari K, Dillin A.  

Mitochondrial Subtype Identification and Characterization. 

Curr Protoc Cytome.  2018 July.  PMID:  29944197

Moehle EA, Shen K, Dillin A.  

Mitochondrial Proteostasis in the Context of Cellular and Organismal Heath and Aging.  J Biol Chem. 2018 Apr 5.  PMID:  29622680

2017

Riera CE.

ThermoTRPs: Role in Aging

Neurobiology of TRP Channels. 2nd ed. CRC Press/Taylor& Francis; 2017. Chapter 14.  PMID:  29356483

Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Dev Cell. 2017 Jul 10;42(1):9-21.  PMID:  28697336

Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.

The Sense of Smell Impacts Metabolic Health and Obesity.

Cell Metab. 2017 Jul 5;26(1):198-211.  PMID:  28683287

Frakes AE, Dillin A.

The UPRER: Sensor and Coordinator of Organismal Homeostasis.

Mol Cell. 2017 Jun 15;66(6):761-771.  PMID:  28622521

2016

Kim, HE, Durieux J, Grant A, Simic, M, Kohnz, R, Nomura, D, Durieuxm J, Riera, C, Sanchez, M, Kapernick, E, Wolff S, Dillin A.  

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.  

Cell.  2016 Sept 8.  PMID: 27610574

Riera, C.E., Merkwirth C., de Magalhaes Filho, C.D. and Dillin, A.

Signaling Networks Determining Life Span 

Annu Rev Biochem. 2016 Jun 2;85:35-64.  PMID: 27294438

Steffen, KK, Dillin A.  

A Ribosomal Perspective on Proteostasis and Aging.  

Cell Metabolism.  2016 June 14.  PMID: 27304502

Riera, C.E., and Dillin, A.

Emerging role of sensory perception in aging and metabolism

Trends Endocrinol Metab. 2016 May;27(5):294-303.  PMID: 27067041 

Daniele JR, Heydari K, Arriaga EA, Dillin A.  

Identification and characterization of mitochondrial subtypes in C. elegans via analysis of individual mitochondria by flow cytometry.  

Anal Chem. 2016 May 23.  PMID: 27210103  

Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A. 

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.  

Cell. 2016 May 165, 1–15.  PMID: 27133168  

Tian Y, Garcia G, Bian Q, Steffen KK, Joe L, Wolff S, Meyer BJ, Dillin A. Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPRmt.  

Cell. 2016 May 165, 1–12.  PMID: 27133166

Seah NE, de Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, Lapierre LR.  

Autophagy-mediated longevity is modulated by lipoprotein biogenesis.  

Autophagy. 2016 12:2 26-272.  PMID: 26671266 

Pre - 2016

Douglas, P, Baird N, Simic M, Uhlein S, McCormick M, Kennedy B, Dillin A.  

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Logevity.  

Cell Reports 12, 1196–1204 August 18, 2015.  PMID: 26257177 

Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, Wolff SC, Yates JR 3rd, Manning G, Dillin A.

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span. 

Science. 2014 Oct 17;346(6207):360-3.  PMID: 25324391

Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A. 

TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. 

Cell. 2014;157(5):1023-36.  PMID: 24855942 

Wolff S, Dillin A. 

Cell biology:  The stressful influence of microbes. 

Nature. 2014;508(7496):328-9.  PMID: 24695220  

Wolff S, Weissman JS, Dillin A. 

Differential scales of protein quality control. 

Cell. 2014;157(1):52-64.  PMID: 24679526  

Taylor RC, Dillin A.

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. 

Cell. 2013;153(7):1435-47.  PMID: 23791175  

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Wolff S, Dillin A.

Aging: beneficial miscommunication. 

Nature. 2013;497(7450):442-3.  PMID: 23698438   

Vilchez D, Boyer L, Morantte I, Lutz, M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, and Dillin A. 

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. 

Nature. 2012: 489(7415):304-8.  PMID: 22972301

Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues, APC, Manning G, and Dillin A. 

RPN-6 determines C. elegans longevity under proteotoxic stress conditions. 

Nature. 2012:389(7415):263-268.  PMID: 22922647 

Durieux J, Wolff S, Dillin A.

The cell-non-autonomous nature of electron transport chain-mediated longevity. 

Cell. 2011;144(1):79-91.  PMID: 21215371  

Additional Publications