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Publications: Image
Publications
2024
Tsui CK, Twells N, Doan E, Brooks J, Kulepa A, Webster B, Mahal LK, Dillin A.
Combinatorial CRISPR screens and lectin microarrays identify novel glycosylation regulators.
bioRxiv. 2024. Preprint. PMID: 37961200
Tharp KM, Park S, Timblin GA, Richards AL, Berg JA, Twells NM, Riley NM, Peltan EL, Shon DJ, Stevenson E, Tsui K, Palomba F, Lefebvre AEYT, Soens RW, Ayad NME, Hoeve-Scott JT, Healy K, Digman M, Dillin A, Bertozzi CR, Swaney DL, Mahal LK, Cantor JR, Paszek MJ, Weaver VM.
The microenvironment dictates glycocalyx construction and immune surveillance.
Res Sq. 2024. Preprint. PMID: 37645943
Shen K, Durieux J, Mena CG, Webster BM, Tsui KC, Zhang H, Joe L, Berendzen K, Dillin A.
The Germline Coordinates Mitokine Signaling
Cell. August 2024. PMID: 8959891
Zhang, H., Tsui CK, Garcia, G., Joe, LK, Wu, H., Maruichi, A., Fan, W., Pandovski, S., Yoon, PH, Webster, BM, Durieux, J., Frankino, P., Higuchi-Sanabria, R., Dillin A.
The Extracellular Matrix Integrates Mitochondrial Homeostasis
Cell. August 2024. PMID: 38942015
Dishart, JG, Pender, C., Zhang, H., Ly, M., Webb, M., Dillin A.
Olfaction Regulates Peripheral Mitophagy and Mitochondrial Function
Science Advances. June 2024. PMID: 38905346
Metcalf MG, Monshietehadi S, Sahay A, Durieux J, Frakes AE, Velichkovska M, Mena C, Farinas A, Sanchez M, Dillin A.
Cell non-autonomous control of autophagy and metabolism by glial cells.
iScience February 2024. PMID: 38500817
2023
Bar-Ziv R, Dutta N, Hruby A, Sukarto E, Averbukh M, Alcala A, Henderson HR, Durieux J, Tronnes SU, Ahmad Q, Bolas T, Perez J, Dishart JG, Vega M, Garcia G, Higuchi-Sanabria R, Dillin A.
Glial-derived mitochondrial signals impact neuronal proteostasis and aging.
Science Advances. October 13 2023. PMID: 37609253
Garcia, G., Zhang, H., Moreno, S., Tsui, C.K., Webster, B.M., Higuchi-Sanabria, R., and Dillin, A.
Lipid homeostasis is essential for a maximal ER stress response
eLife. July 2023. PMID: 37489956
Garcia, G., Bar-Ziv, R., Averbukh, M., Dasgupta, N., Dutta, N., Zhang, H., Fan, W., Moaddeli, D., Tsui, C.K., Torres, T.C., Alcala, A., Moehle, E.A., Hoang, S., Shalem, O., Adams, P.D., Thorwald, M.A., and Higuchi-Sanabria, R.
Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span
Aging Cell. January 2023. PMID: 36404134
Zhang, H., Li, X., Fan, W., Pandovski, S., Tian, Y. and Dillin, A.
Inter-tissue communication of mitochondrial stress and metabolic health
Life Metabolism. January 7, 2023. PMID: 37538245
2022
Gildea, H.K., Frankino, P.A., Tronnes, S.U., Pender, C.L., Choi, H.O., Hunter, T.D., Cheung, S.S., Frakes, A.E., Sukarto, E., Wickham, K., & Dillin, A.
Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory circuit and serotonin
Science Advances 8. December 9, 2022 PMID: 36490338
Murley, A. and Dillin, A.
Macroautophagy in quiescent and senescent cells: a pathway to longevity?
Trends in Cell Biol.ogy November 19, 2022 PMID: 36490338
Tan, D., Konduri, S., Ertunc, M.E,.. Zhang, P., Wang, J., Chang, T. Pinto, A.F.M., Rocha, A, Donaldson, C.J., Vaughn, J.M., Ludwig, R.G., Willey, E., Iyer, M., Gray, P.C.,. Maher, P., Allen, N.J., Zuchero, J.B., Dillin, A., Mori, M.A., Kohama, S.G., Sigel, D., and Saghatelian, A.
A class of anti-inflammatory lipids decrease with aging in the central nervous system
Nat Chem Biol. October 20, 2022 PMID: 36266352
Murley A, Wickham K, and Dillin A.
Life in lockdown: Orchestrating endoplasmic reticulum and lysosome homeostasis for quiescent cells.
Molecular Cell. August 30, 2022 PMID: 36044901
Frankino, P., Siddiqi, T., Bolas, T., Bar-Ziv, R., Gildea, H., Zhang,, H., Higuchi-Sanabria, R., and Dillin, A.
SKN-1 regulates stress resistance downstream of amino catabolism pathways
iScience 25, 104571, July 15, 2022 PMID: 35784796
Shen K, Pender CL, Bar-Ziv R, Zhang H, Wickham K, Willey E, Durieux J, Ahmad Q, and Dillin A.
Mitochondria as Cellular and Organismal Signaling Hubs
Annu Rev Cell Dev Biol. July 8, 2022 PMID: 36044901
Xin, N., Durieux, J., Yang, C., Wolff, S., Kim, HE, and Dillin, A.
The UPRmt preserves mitochondrial import to extend lifespan
Journal of Cell Biology. May 2022 Vol. 221 No. 7 PMID: 35608535
Ward CP, Peng L, Yuen S, Halstead J, Palacios H, Nyangau E, Mohammed H, Ziari N, Dandan M, Frakes AE, Gildea HK, Dillin A, & Hellerstein MK
Aging alters the metabolic flux signature of the ER-unfolded protein response in vivo in mice.
Aging Cell. February 16, 2022 PMID: 35170180
Homentcovschi S and Higuchi-Sanabria R
A neuron’s ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan
Neural Regeneration Research. Feb 2022: 17 (2) PMID: 34269195
Ward, C., Peng, L ., Yuen, S., Chang, M., Karapetyan, R., Nyangau, E., 1, Mohammed, H., Palacios, H., Ziari, N., Joe, L., Frakes, A., Dandan, M., Dillin, A., and Hellerstein, M.
ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes
International Journal of Medical Sciences. January 2022; 23 PMID: 35170180
2021
Moehle, E.*, Higuchi-Sanabria, R.*, Tsui, K., Homentcovschi, S., Tharp, K., Zhang, H., Chi, H., Joe, L., de los Rios Rogers, M., Sahay, A., Kelet, N., Benitez, C., Bar-Ziv, R., Garcia, G., Shen, K., Frankino, P., Schinzel, R., Shalem, O., and Dillin A.
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization
Science Advances. October 2021; 7 PMID: 34714674
Vlassakis J, Hansen LL, Higuchi-Sanabria R, Zhou Y, Tsui CK, Dillin A, Huang H, Herr AE.
Measuring expression heterogeneity of single-cell cytoskeletal protein complexes
Nat Commun. 2021 Aug 17;12(1) PMID: 34404787
Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM.
Adhesion-mediated mechanosignaling forces mitohormesis.
Cell Metab. July 2021: 6;33(7). PMID: 34019840
Tsui CK, Dishart JG, Dillin A.
Brains and brawn: Stress-induced myokine abates nervous system aging.
Cell Metab. 2021 Jun 2021; 1;33(6) PMID: 34077712
2020
Higuchi-Sanabria R, Durieux J, Kelet N, Homentcovschi S, de Los Rios Rogers M, Monshietehadi S, Garcia G, Dallarda S, Daniele JR, Ramachandran V, Sahay A, Tronnes SU, Joe L, and Dillin A.
Divergent Nodes of Non-autonomous UPR ER Signaling through Serotonergic and Dopaminergic Neurons
Cell Rep. 08 Dec 2020: 8;33(10). PMID: 33296657
Metcalf, MG, Higuchi-Sanabria, R, Garcia, G, Tsui, K, and Dillin, A
Beyond the cell factory: Homeostatic regulation of and by the UPRER
Sci Adv. 15 July 2020: 6(29):eabb9614. PMID: 32832649
Webster BM, Gildea HK, Dillin A.
Protein homeostasis from the outside in
Nat Cell Biol. 08 July 2020: Vol. 22, 911-912. PMID: 32641767
Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, Monshietehadi S, Dallarda S, Pender C, Pon LA, Zoncu R, Dillin A.
Lysosomal recycling of amino acids affects ER quality control.
Sci Adv. 26 June 2020: 6(26):eaaz9805. PMID: 32637599
Bar-Ziv R, Bolas T, Dillin A.
Systemic effects of mitochondrial stress.
EMBO Reports. 24 May 2020: 21: e50094. PMID: 32449292
Bar-Ziv, R, Frakes, AF, Higuchi-Sanabria, R, Bolas, T, Frankino, P, Gildea, H, Metcalf, M, and Dillin, A.
Measurements of physiological stress responses in C. elegans.
J Vis Exp. 2020 May 21;(159) PMID: 32510480
Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Higuchi-Sanabria R, Dillin A.
Four glial cells regular ER stress resistance and longevity via neuropeptide signaling.
Science. 24 Jan 2020: Vol. 367, Issue 6476, pp. 436-440. PMID: 31974253
Publications: About
Daniele J, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes S, Kelet N, Sanchez M, Metcalf M, Garcia G, Frankino P, Benitez C, Zeng M, Esping S, Joe L, & Dillin A.
A non-canonical UPRER promotes lipophagy to extend lifespan.
Science Advances. 2020 Jan 1; (6) 1:1-9. PMID: 31911951
Publications: About
2019
Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A.
The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER.
Publications: About
Youssar, L., Wernet, V., Hensel, N., Yu, X., Hildebrand, H., Schreckenberger, B., Kriegler, M., Hetzer, B., Frankino, P., Dillin, A., & Fischer, R.
Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans.
PLOS Genetics. 2019 March 2019. PMID: 30917129
Publications: About
2017
Riera CE.
ThermoTRPs: Role in Aging
Neurobiology of TRP Channels. 2nd ed. CRC Press/Taylor& Francis; 2017. Chapter 14. PMID: 29356483
Publications: About
Publications: About
Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.
DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
Dev Cell. 2017 Jul 10;42(1):9-21. PMID: 28697336
Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.
The Sense of Smell Impacts Metabolic Health and Obesity.
Cell Metab. 2017 Jul 5;26(1):198-211. PMID: 28683287
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Frakes AE, Dillin A.
The UPRER: Sensor and Coordinator of Organismal Homeostasis.
Mol Cell. 2017 Jun 15;66(6):761-771. PMID: 28622521
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