Publications

2022

Frankino, P., Siddiqi, T., Bolas, T., Bar-Ziv, R., Gildea, H., Zhang,, H., Higuchi-Sanabria, R., and Dillin, A.

SKN-1 regulates stress resistance downstream of amino catabolism pathways

iScience 25, 104571, July 15, 2022  PMID:  35784796

Siddiqi, TF., Frankino, PA., Dillin, A.

Tyrosine catabolites influence SKN-1 signaling in a model of Type I Tyrosinemia.

microPublication Biology. 2022 10.17912   PMID:  35668715

Xin, N., Durieux, J., Yang, C., Wolff, S., Kim, HE, and Dillin, A.
The UPRmt preserves mitochondrial import to extend lifespan
Journal of Cell Biology.  May 2022 Vol. 221 No. 7   PMID:  ​​35608535

Homentcovschi S and Higuchi-Sanabria R

A neuron’s ambrosia:  non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan

Neural Regeneration Research.  Feb 2022: 17 (2) PMID:  34269195

Ward, C., Peng, L ., Yuen, S., Chang, M., Karapetyan, R., Nyangau, E., 1, Mohammed, H., Palacios, H., Ziari, N., Joe, L., Frakes, A., Dandan, M., Dillin, A., and Hellerstein, M.
ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes
International Journal of Medical Sciences.  January 2022; 23  PMID:  35170180​​

2021
 
Moehle, E.*, Higuchi-Sanabria, R.*, Tsui, K., Homentcovschi, S., Tharp, K., Zhang, H., Chi, H., Joe, L., de los Rios Rogers, M., Sahay, A., Kelet, N., Benitez, C., Bar-Ziv, R., Garcia, G., Shen, K., Frankino, P.,  Schinzel, R., Shalem, O., and Dillin A.
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization
Science Advances.  October 2021; 7  PMID:  34714674​

Vlassakis J, Hansen LL, Higuchi-Sanabria R, Zhou Y, Tsui CK, Dillin A, Huang H, Herr AE.
Measuring expression heterogeneity of single-cell cytoskeletal protein complexes
Nat Commun. 2021 Aug 17;12(1) PMID: 34404787​

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Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM.
Adhesion-mediated mechanosignaling forces mitohormesis.
Cell Metab.  July 2021: 6;33(7). PMID: 34019840

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Tsui CK, Dishart JG, Dillin A.
Brains and brawn: Stress-induced myokine abates nervous system aging.
Cell Metab. 2021 Jun 2021; 1;33(6) PMID: 34077712

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2020
 
Higuchi-Sanabria R, Durieux J, Kelet N, Homentcovschi S, de Los Rios Rogers M, Monshietehadi S, Garcia G, Dallarda S, Daniele JR, Ramachandran V, Sahay A, Tronnes SU, Joe L, and Dillin A.
Divergent Nodes of Non-autonomous UPR ER Signaling through Serotonergic and Dopaminergic Neurons
Cell Rep.  08 Dec 2020: 8;33(10). PMID: 33296657

Metcalf, MG, Higuchi-Sanabria, R, Garcia, G, Tsui, K, and Dillin, A
Beyond the cell factory: Homeostatic regulation of and by the UPRER
Sci Adv. 15 July 2020: 6(29):eabb9614. PMID: 32832649

Webster BM, Gildea HK, Dillin A.
Protein homeostasis from the outside in
Nat Cell Biol.  08 July 2020: Vol. 22, 911-912. PMID: 32641767  

Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, Monshietehadi S, Dallarda S, Pender C, Pon LA, Zoncu R, Dillin A.
Lysosomal recycling of amino acids affects ER quality control.
Sci Adv.  26 June 2020: 6(26):eaaz9805.  PMID: 32637599

Bar-Ziv R, Bolas T, Dillin A. 
Systemic effects of mitochondrial stress.
EMBO Reports.  24 May 2020: 21: e50094. PMID: 32449292  

Bar-Ziv, R, Frakes, AF, Higuchi-Sanabria, R, Bolas, T, Frankino, P, Gildea, H, Metcalf, M, and Dillin, A.

Measurements of physiological stress responses in C. elegans. 

J Vis Exp. 2020 May 21;(159)  PMID:  32510480 

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Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Higuchi-Sanabria R, Dillin A. 
Four glial cells regular ER stress resistance and longevity via neuropeptide signaling. 
Science.  24 Jan 2020: Vol. 367, Issue 6476, pp. 436-440. PMID:  31974253  

Daniele J, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes S, Kelet N,  Sanchez M, Metcalf M, Garcia G, Frankino P, Benitez C, Zeng M, Esping S, Joe L, & Dillin A. 
A non-canonical UPRER promotes lipophagy to extend lifespan.   
Science Advances.  2020 Jan 1; (6) 1:1-9.  PMID:  31911951   

Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A. 

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. 

Cell. 2019 Nov 27;179(6):1306-1318.  PMID:  31761535

Anderson EC, Frankino PA, Higuchi-Sanabria R, Yang Q, Bian Q, Podshivalova K, Shin A, Kenyon C, Dillin A, Meyer BJ. 
X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.
Dev Cell. 2019 Oct 21;51(2):192-207.    PMID:  31495695   pdf

Simic M, Moehle E, Schinzel, R, Lorbeer F, Halloran J, Heydari, K , Sanchez M, Jullié D , Hockemeyer D , Dillin A. 
Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming.   
Science Advances.  2019 April 20.  PMID:  30989118   pdf

2018

Higuchi-Sanabria R, Paul JW, Durieux J, Benitez C, Frankino PA, Tronnes SU, Garcia G, Daniele JR, Monshietehadi S, Dillin A. 

Spatial regulation of the actin cytoskeleton by HSF-1 dring aging. 

Mol Biol Cell.  2018 Aug 22.  PMID:  30133343   pdf  

Zhang, Q, Wu, X, Chen P, Liu, L, Xin, N, Tian Y, Dillin, A. 
The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.   
Cell.  2018 Aug 9.  PMID:  30057120