Publications

2020

Higuchi-Sanabria, R*, Durieux, J*, Kelet, N, Homentcovschi, S, Monshietehadi, S, Garcia, G, Dallarda, S, Daniele JR, Ramachandran, V,  Tronnes, S, Joe, L, and Dillin A.

Divergent nodes of non-autonomous UPRER signaling through serotonergic and dopaminergic neurons. 

Science.  In Press.

Bar-Ziv, R, Frakes, AF, Higuchi-Sanabria, R, Bolas, T, Frankino, P, Gildea, H, Metcalf, M, and Dillin, A.

Measurements of physiological stress responses in C. elegans. 

JOVE.  In Press.  

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Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Higuchi-Sanabria R, Dillin A. 

Four glial cells regular ER stress resistance and longevity via neuropeptide signaling. 

Science.  24 Jan 2020: Vol. 367, Issue 6476, pp. 436-440. PMID:  31974253  

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Daniele J, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes S, Kelet N,  Sanchez M, Metcalf M, Garcia G, Frankino P, Benitez C, Zeng M, Esping S, Joe L, & Dillin A. 

A non-canonical UPRER promotes lipophagy to extend lifespan.   

Science Advances.  2020 Jan 1; (6) 1:1-9.  PMID:  31911951   

2019

Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A. 

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. 

Cell. 2019 Nov 27;179(6):1306-1318.  PMID:  31761535

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Anderson EC, Frankino PA, Higuchi-Sanabria R, Yang Q, Bian Q, Podshivalova K, Shin A, Kenyon C, Dillin A, Meyer BJ.  X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.

Dev Cell. 2019 Oct 21;51(2):192-207.    PMID:  31495695   pdf

Simic M, Moehle E, Schinzel, R, Lorbeer F, Halloran J, Heydari, K , Sanchez M, Jullié D , Hockemeyer D , Dillin A. 

Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming.   

Science Advances.  2019 April 20.  PMID:  30989118   pdf

2018

Higuchi-Sanabria R, Paul JW, Durieux J, Benitez C, Frankino PA, Tronnes SU, Garcia G, Daniele JR, Monshietehadi S, Dillin A. 

Spatial regulation of the actin cytoskeleton by HSF-1 dring aging. 

Mol Biol Cell.  2018 Aug 22.  PMID:  30133343   pdf  

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Zhang, Q, Wu, X, Chen P, Liu, L, Xin, N, Tian Y, Dillin, A. 

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling.   

Cell.  2018 Aug 9.  PMID:  30057120

Daniele JR, Heydari K, Dillin A.  

Mitochondrial Subtype Identification and Characterization. 

Curr Protoc Cytome.  2018 July.  PMID:  29944197

Moehle EA, Shen K, Dillin A.  

Mitochondrial Proteostasis in the Context of Cellular and Organismal Heath and Aging.  J Biol Chem. 2018 Apr 5.  PMID:  29622680

2017

Riera CE.

ThermoTRPs: Role in Aging

Neurobiology of TRP Channels. 2nd edition. CRC Press/Taylor & Francis; 2017. Chapter 14.  PMID:  29356483

Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Dev Cell. 2017 Jul 10;42(1):9-21.  PMID:  28697336

Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A.

The Sense of Smell Impacts Metabolic Health and Obesity.

Cell Metab. 2017 Jul 5;26(1):198-211.  PMID:  28683287

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Frakes AE, Dillin A.

The UPRER: Sensor and Coordinator of Organismal Homeostasis.

Mol Cell. 2017 Jun 15;66(6):761-771.  PMID:  28622521

2016

Kim, HE, Durieux J, Grant A, Simic, M, Kohnz, R, Nomura, D, Durieuxm J, Riera, C, Sanchez, M, Kapernick, E, Wolff S, Dillin A.  

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.  

Cell.  2016 Sept 8.  PMID: 27610574

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Riera, C.E., Merkwirth C., de Magalhaes Filho, C.D. and Dillin, A.

Signaling Networks Determining Life Span 

Annu Rev Biochem. 2016 Jun 2;85:35-64.  PMID: 27294438

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Steffen, KK, Dillin A.  

A Ribosomal Perspective on Proteostasis and Aging.  

Cell Metabolism.  2016 June 14.  PMID: 27304502

Riera, C.E., and Dillin, A.

Emerging role of sensory perception in aging and metabolism

Trends Endocrinol Metab. 2016 May;27(5):294-303.  PMID: 27067041 

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Daniele JR, Heydari K, Arriaga EA, Dillin A.  

Identification and characterization of mitochondrial subtypes in C. elegans via analysis of individual mitochondria by flow cytometry.  

Anal Chem. 2016 May 23.  PMID: 27210103  

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Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A. 

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.  

Cell. 2016 May 165, 1–15.  PMID: 27133168   pdf   review

Tian Y, Garcia G, Bian Q, Steffen KK, Joe L, Wolff S, Meyer BJ, Dillin A. Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPRmt.  

Cell. 2016 May 165, 1–12.  PMID: 27133166

Seah NE, de Magalhaes Filho CD, Petrashen AP, Henderson HR, Laguer J, Gonzalez J, Dillin A, Hansen M, Lapierre LR.  

Autophagy-mediated longevity is modulated by lipoprotein biogenesis.  

Autophagy. 2016 12:2 26-272.  PMID: 26671266 

Riera, C.E., and Dillin, A. (2015).

Can aging be "drugged"? 

Nat. Med.  2015 Dec 8;21(12):1400-5.  PMID: 26646496

Douglas, P, Baird N, Simic M, Uhlein S, McCormick M, Kennedy B, Dillin A.  

Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Logevity.  

Cell Reports 12, 1196–1204 August 18, 2015.  PMID: 26257177 

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Heimbucher T, Liu Z, Bossard C, McCloskey R, Carrano A, Riedel C. Tanasa B, Klammt C, Fonslow B, Riera C, Lillemeier B, Kemphues K, Yates J, O'Shea C. Hunter T, Dillin A.  

The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function In Metabolism and Longevity.  

Cell Metabolism 22, 151-163, July 7, 2015.  PMID:  26154057 

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Riera CE, Dillin A.  

Tipping the metabolic scales towards increased longevity in mammals.  

Nat Cell Biolo. 2015 Feb 27;17(3):196-203.  PMID:  25720959 

Schinzel R, Dillin A.

Endocrine aspects of organelle stress - cell non-autonomous signaling of mitochondria and the ER. 

Curr Opin Cell Biol. 2015 Feb 9;33C:102-110. PMID: 25677685.

Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M.

Phosphorylation of LC3 by the Hippo kinases STK3/STK4 is essential for autophagy. 

Mol Cell. 2015 Jan 8;57(1):55-68.  PMID: 25544559 

2014

Vilchez D, Seaz I, Dillin A.  

The role of protein clearance mechanisms in organismal ageing and age-related diseases. 

Nat Commun. 2014 Dec 8;5:5659.  PMID:  25482515   

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Dillin A. 

Profile of Kazutoshi Mori and Peter Walter, 2014 Lasker Basic Medical Research awardees: The unfolded protein response. 

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17696-7.  PMID: 25480547 

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Baird NA, Douglas PM, Simic MS, Grant AR, Moresco JJ, Wolff SC, Yates JR 3rd, Manning G, Dillin A.

HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span. 

Science. 2014 Oct 17;346(6207):360-3.  PMID: 25324391

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Mardones P, Dillin A, Hetz C.

Cell-nonautonomous control of the UPR: mastering energy homeostasis. 

Cell Metab. 2014 Sep 2;20(3):385-7.  PMID: 25185942 

Patti GJ, Tautenhahn R, Johannsen D, Kalisiak E, Ravussin E, Brüning JC, Dillin A, Siuzdak G.

Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension. 

Metabolomics. 2014 Aug 1;10(4):737-743.  PMID: 25530742 

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Fonslow BR, Moresco JJ, Tu PG, Aalto AP, Pasquinelli AE, Dillin AG, Yates III, JR. 

Mass spectrometry-based shotgun proteomic analysis of C. elegans protein complexes. 

WormBook. 2014:1-18.PMID: 24967700  

Riera CE, Huising MO, Follett P, Leblanc M, Halloran J, Van Andel R, de Magalhaes Filho CD, Merkwirth C, Dillin A. 

TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling. 

Cell. 2014;157(5):1023-36.  PMID: 24855942 

Carrano AC, Dillin A, Hunter T. 

A Kruppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. 

Nat Commun. 2014;5:3772.  PMID: 24805825   

Wolff S, Dillin A. Cell biology:

The stressful influence of microbes. 

Nature. 2014;508(7496):328-9.  PMID: 24695220  

Wolff S, Weissman JS, Dillin A. 

Differential scales of protein quality control. 

Cell. 2014;157(1):52-64.  PMID: 24679526  

Douglas PM, Dillin A.

The disposable soma theory of aging in reverse. 

Cell Res. 2014.  PMID: 24189044   

Taylor RC, Berendzen KM, Dillin A. 

Systemic stress signalling: understanding the cell non-autonomous control of proteostasis. 

Nat Rev Mol Cell Biol. 2014;15(3):211-7.  PMID: 24556842   

Dillin A, Gottschling DE, Nystrom T. 

The good and the bad of being connected: the integrons of aging. 

Curr Opin Cell Biol.;26:107-12.  PMID: 24529252  

2013

Taylor RC, Dillin A.

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. 

Cell. 2013;153(7):1435-47.  PMID: 23791175  

Le Coutre J, Mattson MP, Dillin A, Friedman J, Bistrian B. 

Nutrition and the biology of human ageing: cognitive decline/food intake and caloric restriction. 

J Nutr Health Aging. 2013;17(8):717-20.  PMID: 24097030   

Vilchez D, Simic MS, Dillin A.

Proteostasis and aging of stem cells. 

Trends in cell biology. 2013.  PMID: 24094931  

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Wolff S, Dillin A.

Aging: beneficial miscommunication. 

Nature. 2013;497(7450):442-3.  PMID: 23698438   

Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A.

FOXO4 is necessary for neural differentiation of human embryonic stem cells. 

Aging Cell. 2013;12(3):518-22.  PMID:  23551888   

Lapierre LR, De Magalhaes Filho CD, McQuary PR, Chu CC, Visvikis O, Chang JT, Gelino S, Ong B, Davis AE, Irazoqui JE, Dillin A, Hansen M. 

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. 

Nat Commun. 2013;4:2267.  PMID: 23925298   

Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. 

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. 

Nat Cell Biol. 2013 Jul;15(7):741-50.  PMID: 23685627  

Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. 

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. 

Nat Cell Biol. 2013 May;15(5):491-501.  PMID: 23604319   

2012

Vilchez D, Boyer L, Morantte I, Lutz, M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, and Dillin A. 

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. 

Nature. 2012: 489(7415):304-8.  PMID: 22972301 

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Vilchez D, Morantte I, Liu Z, Douglas PM, Merkwirth C, Rodrigues, APC, Manning G, and Dillin A. 

RPN-6 determines C. elegans longevity under proteotoxic stress conditions. 

Nature. 2012:389(7415):263-268.  PMID: 22922647 

Parrish AR, She X, Xiang Z, Coin I, Shen Z, Briggs SP, Dillin A, Wang L. 

Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs. 

ACS Chem Biol. 2012 Jul 20;7(7):1292-302.  PMID: 22554080  

Wilkinson DS, Taylor RC, Dillin A.

Analysis of aging in Caenorhabditis elegans. 

Methods Cell Biol. 2012;107:353-81.  PMID: 22226530   

2011

Mair W, Morantte I, Rodrigues AP, Manning G, Montminy M, Shaw RJ, Dillin A.

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.

Nature. 2011;470(7334):404-8.  PMID: 21331044  

Durieux J, Wolff S, Dillin A.

The cell-non-autonomous nature of electron transport chain-mediated longevity. 

Cell. 2011;144(1):79-91.  PMID: 21215371  

Dillin A, Cohen E.

Aging and protein aggregation-mediated disorders: from invertebrates to mammals. 

Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):94-8.  PMID: 21115535  

Taylor RC, Dillin A.

Aging as an event of proteostasis collapse. 

Cold Spring Harb Perspect Biol. 2011;3(5).  PMID: 21441594   

Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA. 

Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. 

Mol Cell. 2011; 44(4):532-44.  PMID: 22099302  

Mair W, Steffen KK, Dillin A.

SIP-ing the elixir of youth. 

Cell. 2011;146(6):859-60.  PMID: 21925309  

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. 

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. 

Science. 2011;331(6016):456-61.  PMID: 21205641  

2010

Volovik Y, Maman, M, Dubnikov, T,  Bejerano-Sagie,M, Joyce D, Kapernick EA, Cohen E, Dillin A.

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. 

Aging Cell.2010;9(2):126-34.  PMID: 22360389  

Douglas PM, Dillin A.

Protein homeostasis and aging in neurodegeneration. 

J Cell Biol. 2010;190(5):719-29.  PMID: 20819932  

Dillin A.

Andy Dillin: Using aging research to probe biology. Interview by Caitlin Sedwick. 

J Cell Biol. 2010;189(4):616-7.  PMID: 20479463  

2009

Mair W, Panowski SH, Shaw RJ, Dillin A.

Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. 

PLoS One. 2009;4(2):e4535.  PMID: 19229346 

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Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A.

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.

Cell. 2009;139(6):1157-69.  PMID: 20005808  

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Carrano AC, Liu Z, Dillin A, Hunter T.

A conserved ubiquitination pathway determines longevity in response to diet restriction. 

Nature. 2009;460(7253):396-9. PMID: 19553937  

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Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE.

Biological and chemical approaches to diseases of proteostasis deficiency. 

Annu Rev Biochem. 2009;78:959-91.  PMID: 19298183  

Panowski SH, Dillin A.

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. 

Trends Endocrinol Metab. 2009;20(6):259-64.  PMID: 19646896.   p

Shaw R, Dillin A. 

PPTR-1 counterAkts insulin signaling. 

Cell. 2009;136(5):816-8.  PMID: 19269361 

2008

Mair W, Dillin A.

Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem. 2008;77:727-54.  PMID: 18373439

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Cohen E, Dillin A.

The insulin paradox: aging, proteotoxicity and neurodegeneration. 

Nature reviews Neuroscience. 2008;9(10):759-67.  PMID: 18769445  

Balch WE, Morimoto RI, Dillin A, Kelly JW.

Adapting proteostasis for disease intervention. 

Science. 2008;319(5865):916-9.  PMID: 18276881   

Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J.

C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. 

Cell. 2008;132(5):745-57.  PMID: 18329362

2007

Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A.

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. 

Nature. 2007;447(7144):550-5.  PMID: 17476212

Dong MQ, Venable JD, Au N, Xu T, Park SK, Cociorva D, Johnson JR, Dillin A, Yates JR.

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. 

Science. 2007;317(5838):660-3.  PMID: 17673661

Durieux J, Dillin A.

Mitochondria and aging: dilution is the solution. 

Cell Metab. 2007;6(6):427-9.  PMID: 18054312   pdf  

2006

Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A.

Opposing activities protect against age-onset proteotoxicity. 

Science. 2006;313(5793):1604-10.  PMID: 16902091

Wolff S, Ma H, Burch D, Maciel GA, Hunter T, Dillin A.

SMK-1, an essential regulator of DAF-16-mediated longevity. 

Cell. 2006;124(5):1039-53.  PMID: 16530049  

Wolff S, Dillin A.

The trifecta of aging in Caenorhabditis elegans.

Experimental gerontology. 2006;41(10):894-903.  PMID: 16919905   

2005

Raices M, Maruyama H, Dillin A, Karlseder J.

Uncoupling of longevity and telomere length in C. elegans. 

PLoS Genet. 2005;1(3):e30.  PMID: 16151516  

Hansen M, Hsu AL, Dillin A, Kenyon C.

New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.

PLoS Genet. 2005;1(1):119-28.  PMID: 16103914 

Aguilaniu H, Durieux J, Dillin A.

Metabolism, ubiquinone synthesis, and longevity. 

Genes & development. 2005;19(20):2399-406.  PMID: 16230529  

Pre 2005

Venable JD, Dong MQ, Wohlschlegel J, Dillin A, Yates JR.

Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra. 

Nature Methods. 2004;1(1):39-45.  PMID: 15782151 

Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C.

Rates of behavior and aging specified by mitochondrial function during development. 

Science. 2002;298(5602):2398-401.  PMID: 12471266 

Dillin A, Crawford DK, Kenyon C.

Timing requirements for insulin/IGF-1 signaling in C. elegans. 

Science. 2002;298(5594):830-4.  PMID: 12399591 

Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C.

Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. 

Science. 2002;295(5554):502-5.  PMID: 11799246 

Dillin A, Rine J.

Roles for ORC in M phase and S phase. 

Science. 1998;279(5357):1733-7.  PMID: 9497294 

Dillin A, Rine J.

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae. 

Genetics. 1997;147(3):1053-62.  PMID: 9383052 

McCracken AA, Karpichev IV, Ernaga JE, Werner ED, Dillin AG, Courchesne WE.

Yeast mutants deficient in ER-associated degradation of the Z variant of alpha-1-protease inhibitor. 

Genetics. 1996;144(4):1355-62.  PMID: 8978025 

Loo S, Laurenson P, Foss M, Dillin A, Rine J.

Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae. 

Genetics. 1995;141(3):889-902.  PMID: 8582634 

Fox CA, Loo S, Dillin A, Rine J.

The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. 

Genes & Development.1995;9(8):911-24.  PMID: 7774809 

Dillin A, Rine J.

On the origin of a silencer. 

Trends Biochem Sci. 1995;20(6):231-5. PMID: 7631420