LLHF Research Fellow
I received my Bachelor’s degree in Biotechnology from Tel Aviv University, and my M.Sc and Ph.D from the Weizmann Institute of Science in Israel. During my graduate work in Professor Naama Barkai’s lab, I applied high-throughput sequencing based techniques to study the dynamics of chromatin and gene expression during DNA replication. On the chromatin level, I found that histone modifications are retrieved in a transcription-dependent time delay following DNA replication, and that a wave of H3K9 acetylation precedes the replication fork. On the level of gene expression, I showed that the expression of most genes is buffered during DNA replication, and found the first molecular link to the mechanism of this phenomenon.
In the Dillin lab, I am broadly interested in how cells maintain protein homeostasis within different organelles, with particular interest in mitochondrial stress responses. I study the mechanisms responsible for the deterioration of mitochondrial homeostasis during aging, and interested in studying how different tissues respond to mitochondrial stress, focusing on transcriptional regulation and rewiring that occurs during stress and aging.
In addition to my work in the Dillin lab, I volunteer in ScienceAbroad, a non-profit organization of Israeli scientists who are doing research outside of Israel. This non profit has 27 branches around the world, and I manage the UC Berkeley branch. I am also an early-career reviewer for the Genetics Society of America.
Schinzel RT, Higuchi-Sanabria R, Shalem O, Moehle EA, Webster BM, Joe L, Bar-Ziv R, Frankino PA, Durieux J, Pender C, Kelet N, Kumar SS, Savalia N, Chi H, Simic M, Nguyen NT, Dillin A. 2019. The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. Cell. 27;179(6):1306-1318
Frumkin I, Yofe I, Bar-Ziv R, Gurvich Y, Lu YY, Voichek Y, Towers R, Schirman D, Krebber H, Pilpel Y. 2019. Evolution of intron splicing towards optimized gene expression is based on various Cis- and Trans-molecular mechanisms. PLoS Biol. 2019 23;17(8).
Bar-Ziv R, Nguyen NT, Dillin A.Vive ut Numquam Moriturus: Tweaking Translational Control to Regulate Longevity. Molecular Cell. 21;73(4):643-644.
Voichek Y, Mittelman K, Gordon Y, Bar-Ziv R, Lifshitz Smit D, Shenhav R, Barkai N. 2018. Epigenetic Control of Expression Homeostasis during Replication Is Stabilized by the Replication Checkpoint. Molecular Cell. 21;70(6):1121-1133
Milo I, Blecher-Gonen R, Barnett-Itzhaki Z, Bar-Ziv R, Tal O, Gurevich I, Feferman T, Drexler I, Amit I, Bousso P, Shakhar G. 2018. The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation. Eur J Immunol.48(7):1137-1152.
Bar-Ziv R*, Voichek Y*, Barkai N. 2016. Dealing with Gene-Dosage Imbalance during S Phase. Trends in Genetics. 32(11):717-723.
Voichek Y*, Bar-Ziv R*, Barkai N, 2016. A role for Rtt109 in buffering gene-dosage imbalance during DNA replication. Nucleus. 7(4):375-81
Bar-Ziv R*, Voichek Y*, Barkai N, 2016, Chromatin dynamics during DNA replication. Genome Research. 26(9):1245-56.
Voichek Y*, Bar-Ziv R*, Barkai N, 2016, Expression homeostasis during DNA replication. Science. 351(6277):1087-90.
Hornung G, Bar-Ziv R*, Rosin D, Tokuriki N, Tawfik DS, Oren M, Barkai N, 2012, Noise-mean relationship in mutated promoters. Genome Research. 22(12):2409-17.