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Melissa M 2.JPG

NIH F31 Fellow

Ph.D. Candidate, MCB


I received my B.S. from Georgetown University in 2014 where I investigated the role of the protein GPNMB in the autophagosomal pathway in melanocytes.  After graduating, I worked in the lab of Dr. Richard Axel researching representations of olfactory information in the Drosophila brain and developing a new method of measuring neuronal activity. As a doctoral student in the Dillin lab, I am working to understand how glial cells communicate protein stress and maintain homeostasis across tissues.


Frakes AE, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Dillin A.

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans.

Science. 2020 Jan 24;367(6476):436-440. doi: 10.1126/science.aaz6896.

PMID: 31974253; PMCID:PMC7357615.


Metcalf MG, Higuchi-Sanabria R, Garcia G, Tsui CK, Dillin A.

Beyond the cell factory: Homeostatic regulation of and by the UPRER.

Sci Adv. 2020 Jul 15;6(29):eabb9614. doi: 10.1126/sciadv.abb9614.

PMID: 32832649; PMCID:PMC7439504.

Bar-Ziv R, Frakes AE, Higuchi-Sanabria R, Bolas T, Frankino PA, Gildea HK, Metcalf MG, Dillin A.

Measurements of Physiological Stress Responses in C. elegans.

J Vis Exp. 2020 May 21;(159):10.3791/61001. doi: 10.3791/61001.

PMID: 32510480; PMCID: PMC7840273.

Daniele JR, Higuchi-Sanabria R, Durieux J, Monshietehadi S, Ramachandran V, Tronnes SU, Kelet N, Sanchez M, Metcalf MG, Garcia G, Frankino PA, Benitez C, Zeng M, Esping DJ, Joe L, Dillin A.

UPRER promotes lipophagy independent of chaperones to extend life span.

Sci Adv. 2020 Jan 1;6(1):eaaz1441. doi: 10.1126/sciadv.aaz1441.

PMID: 31911951; PMCID: PMC6938708.

Melisssa Metcalf: TeamMember
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