I received my PhD from UCSD where my research in the Dillin Lab focused on characterizing the longevity related to electron transport chain dysfunction. We found a cell non-autonomous response to tissue specific ETC knockdown resulting in upregulation of the mitochondrial unfolded protein response. Continuing in this line of research, as Staff Research Associate, I assist current and former lab members in their projects related to mitochondria, stress, and longevity. We currently study the relationship between disease aggregative proteins and the mitochondrial stress response.
Berendzen, KM, Durieux, J, Shao LW, Tian Y, Kim HE, Wolff S, Liu Y, Dillin A. Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis. Cell. 2016 Sept 8.
Anderson, D., Durieux, J., Song, K., Alvarado, R., Jackson, P., Hatzivassiliou, G., Ludlam, M. Live-cell microscopy assays reveal inhibitor–induced activation within the MAPK pathway. PLoS One. 6. 8(2011).
Durieux, J., S. Wolff & Dillin, A. The Cell Non-Autonomous Nature of Electron Transport Chain Mediated Longevity. Cell. 144, 79-91 (2011).
Durieux, J., & Dillin, A. Dilution Is the Solution. Review. Cell Metab. 6, 427-9 (2007).
Panowski, S., Wolff, S., Aguilaniu, H., Durieux, J., and Dillin, A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature, 447, 550-5 (2007).
Durieux, J., Aguilaniu, H., and Dillin, A. Metabolism, ubiquinone synthesis, and longevity. Review. Genes & Dev., 19, 399-406 (2005).