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Holly 2.JPG

NSF Fellow and NIH F99 Award Recipient

Ph.D. Candidate, Helen Wills Neuroscience


I received my bachelor's degree in neuroscience from Brown University in 2016, where I worked in the lab of Dr. Alexander Jaworski studying the roles of novel axon guidance cues. I started my work in the Dillin lab with Dr. Ashley Frakes, uncovering communication of the ER unfolded protein response between glia, the non-neuronal cells of the brain, and peripheral tissues. Following up on that work, I am collaborating with fellow Dillin lab graduate student Phil Frankino to uncover a role for glia in heat stress in C. elegans. I am also interested in the contributions of glial proteostasis signaling to aging and neurodegenerative disease, both in the worm and mouse model systems.


Bar Ziv R*, Frakes AF*, Higuchi-Sanabria R*, Bolas T**, Frankino PA**, Gildea HK**, Metcalf MG**, Dillin A. Measurement of Physiological Stress Responses in C. elegans. JoVE. In press.

Frakes AF, Metcalf MG, Tronnes SU, Bar-Ziv R, Durieux J, Gildea HK, Kandahari N, Monshietehadi S, Dillin A. Four. glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans. Science. 2020; 367(6476): 436-44

Jaworski A, Tom I, Tong RK, Gildea HK, Koch AW, Gonzalez LC, Tessier-Lavigne M. Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. Science. 2015; 350 (6263): 961-965.

Holly Gildea: Faculty
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